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ESOSPER-D

ESOSPER-D™ Capsules

Introduction: The combination of Esomeprazole and Domperidone is widely used to manage various gastrointestinal disorders, including gastroesophageal reflux disease (GERD), nausea, vomiting, and other gastric motility issues. This combination leverages the distinct mechanisms of action of each drug to offer comprehensive relief for patients suffering from these conditions.

Active Ingredients:

  • Esomeprazole 40mg (ER) (Extended-Release)
    Esomeprazole is a proton pump inhibitor (PPI) that works by reducing the amount of acid produced in the stomach. It is used to treat conditions like acid reflux, GERD, and ulcers. Esomeprazole provides long-lasting relief by suppressing gastric acid secretion and helping to heal acid-related damage in the esophagus and stomach.
  • Domperidone 10mg (IR) (Immediate-Release) / 20mg (SR) (Sustained-Release)
    Domperidone is a dopamine antagonist that helps improve gastric motility. It works by blocking dopamine receptors in the gut, which increases the movement of food through the stomach and intestines, reducing symptoms like nausea and vomiting. Domperidone also has a mild antiemetic effect, making it effective in treating nausea caused by various factors, including acid reflux.

Dosage and Administration:

Dosage and Administration:

Dosage and Administration:

  • Esomeprazole 40mg (ER): Typically taken once daily, preferably before a meal.
  • Domperidone 10mg (IR): Usually taken 15 to 30 minutes before meals to help improve motility and reduce nausea.
  • Domperidone 20mg (SR): Taken once daily for sustained release over time.

Note: The specific dosage may vary depending on individual needs and doctor recommendations. Always follow your healthcare provider’s instructions.

Mechanism of Action:

Dosage and Administration:

Dosage and Administration:

  • Esomeprazole:
    As a proton pump inhibitor, Esomeprazole works by binding to the proton pumps in the stomach lining, preventing them from secreting excess acid. This leads to reduced gastric acidity and helps in healing acid-induced damage, such as ulcers and inflammation of the esophagus.
  • Domperidone:
    Domperidone acts by blocking dopamine receptors in the gastrointestinal tract, which increases motility and accelerates gastric emptying. This helps relieve symptoms like nausea and bloating that occur due to slow digestion. Its sustained-release formulation ensures that it works throughout the day for continuous symptom management.

Precautions and Warnings:

Dosage and Administration:

Precautions and Warnings:

  • Esomeprazole:
    • Long-term use may increase the risk of bone fractures.
    • Can interfere with the absorption of certain vitamins and minerals, like magnesium and vitamin B12.
    • Not recommended for use in combination with certain drugs, such as Clopidogrel.
  • Domperidone:
    • Should be used with caution in patients with heart conditions, as it can affect cardiac rhythm.
    • Not suitable for people with gastrointestinal bleeding, mechanical obstruction, or perforation.
    • Caution is advised for elderly patients or those with liver issues.

Important: Always consult your healthcare provider before starting or combining medications.

Side Effects:

Side Effects:

Precautions and Warnings:

  • Esomeprazole:
    • Common side effects include headache, diarrhea, nausea, and abdominal pain.
    • Serious side effects, although rare, may include kidney problems and severe allergic reactions.
  • Domperidone:
    • Possible side effects include dry mouth, dizziness, and abdominal cramps.
    • Rarely, it may cause heart-related side effects, including arrhythmias, especially at higher doses or in patients with pre-existing heart conditions..

Storage:

Side Effects:

Conclusion:


Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.

Conclusion:

Side Effects:

Conclusion:

The combination of Esomeprazole and Domperidone is an effective solution for managing acid reflux, ulcers, and gastrointestinal motility issues. With its dual action—acid suppression and motility enhancement—it provides comprehensive symptom relief for patients with chronic digestive conditions.Customers have questions, you have answers. Display the most frequently asked questions, so everybody benefits.

Indications:


  • Gastroesophageal Reflux Disease (GERD): Helps in reducing acid reflux and esophageal irritation, providing symptomatic relief.
  • Peptic Ulcers: Assists in promoting ulcer healing and preventing acid-related damage.
  • Nausea and Vomiting: Effective for controlling nausea and vomiting associated with gastric disorders.
  • Gastroparesis (Delayed Gastric Emptying): Aids in improving gastric motility and relieving symptoms such as bloating and fullness.

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